Cancer Genomic Precision Therapy: Digitized Tumor’s Genome (WGSA) Compared with Genome-native Germ Line: Flash-frozen specimen and Formalin-fixed paraffin-embedded Specimen Needed

21 04 2013

Leaders in Pharmaceutical Business Intelligence (LPBI) Group

Curator: Aviva Lev-Ari, PhD, RN

Dr. Charles Swanton, Cancer Research, UK’s London Research Institute explained in his March 29, 2013 interview for Science, that the cancer treatments often fail as a result of the increasing evidence that tumors contain a heterogeneous mix of cells – tissue tagged with colored fluorescent markers for specific molecular changes sh0ws that not all cells in a tumor are the same. SCIENCE vol 339, 3/29/2013, 1543-1545

His team sequenced DNA taken from different parts of a patient’s kidney tumor, the sequence of each part was different. Severaal genetic changes were shared throughout the original tumor mass and iother tumors, or metastases, most were present in only some parts, suggesting that tumors host diverse populations of cells. some of these cells may be resistant to a treatment and continue to grow.

The findings presented below from Swanton’s Lab and from Polyak’s Lab demonstrate that intra-tumor…

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