Food and Drug Administration Reformulation of OxyContin

30 04 2013

AAPS Blog

Abimbola FarindeAbimbola Farinde, Pharm.D., is a clinical pharmacist specialist with specializations in psychopharmacology and geriatrics.

  
The recent Food and Drug Administration (FDA) approval of an abuse deterrent label for the reformulated OxyContin can be viewed by many members of the medical and healthcare community as an indication of the FDA’s growing awareness of the public health crisis and the apparent growth of OxyContin “abuse” to an epidemic “status.” It has been reported that less than 10 percent of the United States population abuses opiates in their lifetime with the street opiate, OxyContin being among the drugs of choice. The new labeling specifically indicates that the associated physical and chemical properties of the new formulation will make it difficult for abuse via intranasal administration. OxyContin manipulation, e.g., crushing, breaking, or dissolving, causes more rapid delivery of the drug to achieve a euphoric effect, but manipulation can also increase the abuser’s…

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