That Was Then, This is Now: Trends in Immunogenicity and Tolerance

30 04 2013

AAPS Blog

Anne DeGrootAnne De Groot, M.D., is professor and director at the University of Rhode Island Institute for Immunology and Informatics.

 
Sometimes handlebar mustaches are in, and sometimes, they are very, very out! The world of fashion is well known for its “emerging trends” and well, it seems that trends are also common in preclinical development of protein therapeutics. Ten years ago, anti-drug antibody (ADA) responses to protein therapeutics were the focus of each and every meeting, while aficionados of T cells (with and without handlebar mustaches) made time to talk about their favorite topic over lunch. At that time, few but the bravest would bring up the concept of doing T cell epitope- focused immunoinformatics analysis of biologic proteins in the preclinical phase of drug development. The T cell-driven immune response, as a contributor to protein immunogenicity, was definitely a “fringe” concept.

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