Emerging Clinical Applications for Cardiac CT: Plaque Characterization, SPECT Functionality, Angiogram’s and Non-Invasive FFR

17 07 2013

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Emerging Clinical Applications for Cardiac CT: Plaque Characterization, SPECT Functionality, Angiogram’s and Non-Invasive FFR

Author, and Content Consultant to e-SERIES A: Cardiovascular Diseases: Justin Pearlman, MD, PhD, FACC


Article Curator: Aviva Lev-Ari, PhD, RN

Clinical studies of coronary anatomy by computed tomography use equipment with various numbers of concurrent slices through the heart: 1, 4, 16, 32, 64, 128, and recently 256 or more. Like interventional catheterization, iodine is injected to make the inside of the coronary arteries opaque to xray transmission, to create contrast (otherwise the xray of the coronary tree would be like a photograph of a white polar bear in a snow storm; the contrast acts like spray paint). Computed tomographic angiography (CTA) uses a similar or higher dye load than catheterization, and provides generally lower imaging quality than catheterization but with 3-dimensional reconstruction instead of flat projection (hundreds of linear views at different angles…

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15 07 2013



15 07 2013

The Number Of Poorly-Reasoned Lawyer Opinion Articles Out There Today — Lead Me To This Trayvon Update

14 07 2013

New Merck, Reviewed

Someone I love and trust predicted that the jury would acquit. I guess I should have thought more about that. I just wanted to believe a little more — in common, color blind — sense. But we are far from the end, here for Mr. Zimmerman’s path before the law.

So… I’ve read several opinion pieces (including this one particularly blowharded version) which suggest that Florida’s Stand Your Ground law was no factor in this case. That is simply incorrect. In 2005, the Florida version of Stand Your Ground removed the duty of any citizen to retreat — if a retreat could safely be acheived — before using deadly force, in a situation like even George Zimmerman’s proffered version of his encounter with Trayvon Martin. [And what of Trayvon’s right to stand his ground? I’ll not cover that in detail, but Trayvon had a right to be…

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FDA Approves New Drug Gilotrif for Advanced Lung Cancer

14 07 2013

New Drug Approvals

File:Afatinib skeletal.svg


FRIDAY July 12, 2013 — A new drug to treat advanced lung cancer has been approved by the U.S. Food and Drug Administration.

Gilotrif (afatinib) is approved to treat patients with a specific subtype of of non-small cell lung cancer (NSCLC). About 85 percent of lung cancers are NSCLC, making it the most common type of lung cancer.

Gilotrif is approved to treat tumors that carry key deletions on the epidermal growth factor receptor (EGFR) gene, long a target for lung cancer therapeutics. Mutations in the EGFR gene are thought to occur in about 10 percent of non-small cell lung cancers, and most of those mutations are targeted by Gilotrif, the FDA said.http://www.drugs.com/news/fda-approves-new-gilotrif-advanced-lung-cancer-45917.html

Afatinib (INN; planned trade name Tomtovok, previously Tovok) is a candidate drug against non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim.  As of July 2012, it is undergoing

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Study links vitamin D deficiency to accelerated bone aging

13 07 2013

Heap Big Stinkum

12 07 2013

Lamentations on Chemistry

The current movie “The Lone Ranger” is a real stinker. The buffoons who produce pictures like this should not be encouraged with good attendance figures. You can’t build a movie solely on a sight gag consisting of Johnny Depp with a dead crow on his head. In fact, I’d rather not invest anymore heartbeats on the topic. <end>

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